It's a form of arthritis that causes sudden pain, redness, swelling, and stiffness. NWFhMTI0MjA5YzcwNzQzMDA2OTI1NDJkNzg1YTQwNmYwOTM2NWRlNTdhMWM0 MmE0YTI1MzZjNjIzMmViY2Y4NjJiYzgwMDYyY2Q3YWUyNjdiYzM1YTIxOTVj Abnormal Blistering of the Skin: The most common symptom of peeling skin syndrome is the abnormal patches of redness and blistering of the skin. In 11 patients with APSS, Pigors et al. M b. Please login or register first to view this content. Acad. Acral PSS: Acral PSS is largely asymptomatic and the skin peeling does not lead to atrophy or scarring of that area. Photograph of both hands. Although the skin peeling occurred spontaneously, manual removal of strips of skin was easy. @inproceedings{Rivero2016AcralPS, title={Acral Peeling Skin Syndrome: A Case Report and Literature Review. Histopathologic examination of the skin shows cleavage at the junction between the stratum corneum and stratum granulosum. The Dutch family included 5 affected individuals in 2 interbred sibships. Derm. Yjg3YmI2MmZhMzVlNzNiZGI3NmYwYTdiYjMxYzQ1YjI3YzU4ZGNkNGJmY2U1 ORPHA: 263534; Cassidy, A. J., van Steensel, M. A. M., Steijlen, P. M., van Geel, M., van der Velden, J., Morley, S. M., Terrinoni, A., Melino, G., Candi, E., McLean, W. H. I. Acral Peeling Skin Syndrome (APSS) is considered to be a localized variant [ 4 ]. Injury, secondary infections, and scarring can arise with scratching of those areas. The genetic defect in Netherton syndrome is in the Spink5 gene which encodes for LEKT1, a serine proteinase inhibitor. Acad. Dont miss out on todays top content on Dermatology Advisor. Federal government websites often end in .gov or .mil. -----END REPORT-----. [PubMed: 19440220, related citations] - Superficial skin peeling (limited to dorsa of hands and feet), - Blistering at junction of stratum granulosum and stratum corneum, - Skin peeling exacerbated by heat, friction, and humidity. Peeling skin is unintended damage to and loss of the upper layer of your skin (epidermis). Consanguinity in the Scottish family could not be determined. Sci. Derm. GALLERY PROFILE; AUSSTELLUNGEN. Patients are managed by long term care with a dermatologist who can monitor disease exacerbations, provide optimal therapeutic relief, and screen for secondary complications of these diseases. The elder sibling was a 13 year old boy who developed peeling of the skin in the first year after birth. -. Bi-allelic disease-causing genetic variants in TGM5 result in loss of function of this important cross-linking enzyme in the upper skin layers. The Licensed Content is the property of and copyrighted by DSM. "Acral" refers to the fact that the peeling is most apparent on the hands and feet, although peeling may also occur on the arms and legs. At least 22 mutations in the TGM5 gene have been found to cause acral peeling skin syndrome. [PubMed: 11100033] NWVjM2U3ZWYyOGQwOGZjZDk5NjUwM2UzYzVmYjkyMzRmNDc0NzEyNjBhNWQ4 [Full Text], van der Velden, J. J. ODJmMWRmMGQ1ZjQzNjJhZGUzMTM2NTdkOTkyYTU2YzY3NjZiODA4ZmNlY2E2 -, Hashimoto K, Hamzavi I, Tanaka K, Shwayder T. Acral peeling skin syndrome. Other diagnostic abnormalities that appear sporadically in case reports were abnormal tryptophan levels, aminoaciduria, elevated serum copper, elevated ceruloplasmin, increased iron and iron-binding capacity, and abnormal epidermal retinoid metabolism. [Full Text: https://doi.org/10.1038/jid.2009.118], Kiritsi, D., Cosgarea, I., Franzke, C.-W., Schumann, H., Oji, V., Kohlhase, J., Bruckner-Tuderman, L., Has, C. Type A PSS is histologically characterized by hyperkeratosis, thinning of the granular layer, and a separation of the stratum corneum from the stratum granulosum or an intracorneal split. Healing occurs spontaneously without scarring or atrophy but there may be erythema in the denuded area. Patients present with asymptomatic widespread white scaling of skin that is most prominent over upper and lower extremities and less prominent on the hands and feet. and by advanced students in science and medicine. Peeling skin syndrome is a rare dermatosis characterized by spontaneous and painless . Haplotype analysis of these 6 families, including 5 from the Netherlands and 1 from Germany, as well as of the 2 Dutch and Scottish families previously studied by Cassidy et al. An official website of the United States government. NTdlYTYxZmMyYmZiMzM0NzFkZDE0MTc1ZjU4MDlmYTA1MzI3OWFjMzE5ODUx YzhmYzJkODk5MWRjZWViYzYzNzZhYjllOWZhNGM3MjRjODM4ODZkMGNmMWRl Skin peeling is caused by sun, humidity, moisture, and friction. Y2Y2MjdjMTU1NWRmOTU3YTZkNzcxODdjYWRlY2FlNmRkMjJlY2FkYzQwYWE1 An extremely rare autosomal recessive genodermatosis (OMIM:609796) characterised by shedding of the outer epidermis, especially of the dorsa of the hands and feet, which is exacerbated by increase ambient temperature and/or humidity. Peeled areas showed some residual erythema for a few days but healed spontaneously and without scarring. J. Report of a Case. The diagnosis of APSS is confirmed with identification of causative mutations in the TGM5 gene using mutation analysis from DNA derived from white blood cells. [Full Text], Shwayder, T., Conn, S., Lowe, L. Arch Dermatol. [Full Text]. Kavaklieva S, Yordanova I, Bruckner-Tuderman L, Has C. Acral peeling skin syndrome resembling epidermolysis bullosa simplex in a 10-month old boy. Case report: They should also be educated about avoiding things that exacerbate the peeling such as water, wind, dust, sand, and friction. Acral peeling skin syndrome with TGM5 gene mutations may resemble epidermolysis bullosa simplex in young individuals. [PubMed: 22622422, related citations] Skin biopsy taken from the palms confirmed peeling skin syndrome. Derm. However, they are not generally itchy. They should also be educated about avoiding exacerbating triggers such as mechanical trauma, humidity, heat, perspiration, and exposure to water. Elevated kallikrein expression in the epidermis and serum results in has been implicated in the angioedema and urticaria that patients develop with this disease. Case Rep Dermatol. Treatment is . Acral PSS: APSS is most commonly due to a mutation in TGM5, which encodes for transglutaminase 5. The word "acral" refers to a condition that affects your peripheral body parts. peeling skin syndrome, acral type. The word "acral" refers to a condition that affects your peripheral body parts. In the older children and the adult patient, peeling of the skin was the most prominent symptom, but blisters occurred occasionally. 1 It presents at birth or in early childhood with the formation of blisters and subsequent peeling on the palms and soles. Invest. Adults can also develop the condition if they have cancer, kidney failure, or thyroid disease. Peeling is more prominent on nonacral areas. 2012 Mar 19;12:2. doi: 10.1186/1471-5945-12-2. For example, cholesterol sulfate plays a crucial role for cohesion and desquamation of the stratum corneum in the epidermis. Occasionally, peeling also occurs on the arms and legs. Generalized noninflammatory/type A PSS: This subtype is characterized by generalized painless white scaling of the skin which is easily and painlessly removed. As the disease has a low incidence and little or no clinical repercussion, it tends to be . The penetration of allergens into the epidermis is thought to be a novel cause of atopic disease, with development of a hypersensitivity reactions to penetrating allergens. 130: 1741-1746, 2010. Affected patients experienced periodic, painless, and superficial skin peeling. Derm. Generalized noninflammatory/Type A PSS: There is no specific treatment for type A PSS. Thank you in advance for your generous support, No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. [Full Text: https://doi.org/10.1016/j.jdermsci.2011.10.002]. FOIA 2007 Mar;46(3):287-9. doi: 10.1111/j.1365-4632.2006.03074.x. Invest. Mjg0MmFiYzUyNjUwZWMzYThhYWEwOWI5OTQyMzVjYTkyNTQxNjM0ZWFmOWZk 2000;43:111219. Histamine is implicated in the inflammatory aspect of this disease and kallikrein inhibitors may also be helpful in patients with type B PSS who develop angioedema. Acral peeling skin syndrome is a genetic skin disorder characterized by painless peeling of the top layer of skin. Scientific Director, OMIM. The mutation was not found in 120 North African controls. Avoiding scratching and other disease exacerbations is recommended. Background: Acral peeling skin syndrome is a rare autosomal recessive disorder in which skin exfoliation is limited to the hands and feet. Photograph of both hands. A 44-year-old woman of African descent, 1 of a set of non-identical twins, presented with recurrent episodes of skin peeling of the upper and lower limbs. }, author={Juncal Ruiz Rivero and Minia Campos Dom{\'i}nguez and Ver{\'o}nica Parra Blanco and Ricardo Su{\'a}rez Fern{\'a}ndez}, year={2016} } J. R . Peeling skin syndrome (PSS) refers to a group of conditions that causes skin to peel and tear easily. Case presentation Two siblings presented with asymptomatic peeling of the hands and the feet. While it typically manifests from early childhood, in this first reported case from South Africa, the patient did not manifest clinically until the fourth decade of life. Table of Contents. Screening for TGM5 is indicated for patients with European ancestry who are suspected of having epidermolysis bullosa simplex but do not have mutations in the associated keratin genes. Acral Peeling Skin Syndrome . Please join your colleagues by making a Note the erythema, swelling and remnant peeling of the. BMC Dermatol. This condition is very rare, and a. Sir, Acral peeling skin syndrome (OMIM #609796), first described in 1921 by Fox, is an autosomal recessive cutaneous disorder caused by mutations in the transglutaminase-5 (TGM5) gene and, less frequently, in the cystatin A (CSTA) gene. YjI2NGMxZjg5N2VlY2JiMzg5YTg2OWNjYjU5YjRjYmRhNDA5MzRkOGM2Yjdh If you wish to read unlimited content, please log in or register below. Cancel. No desmosomal abnormalities were observed, and cleavage occurred in the intercellular spaces between corneocytes. Acral peeling skin syndrome in two East-African siblings: case report. of the OMIM's operating expenses go to salary support for MD and PhD In acral peeling skin syndrome, there is peeling of the skin of the top layers called the epidermis. Peeling happens sometimes on the arms and legs, too. (Letter) New styles in stock Evening Bags Fashion Cute Cartoon Clouds Blue Sky Acrylic Personality Women's Clutch Handbag Bag Shoulder Messenger DailyQuantity Limited promotion - facepaintingcincinnati.com A young man presented to our department with a lifelong history of localized peeling skin of his acral surfaces, especially after exposure to heat, humidity, and/or friction. As noted in a 2019 case letter, acral peeling skin syndrome was first reported in 1921 by Dr. Howard Fox. (2009) sequenced the TGM5 gene and identified homozygosity for a missense mutation (K445N; 603805.0002) that was present in heterozygosity in their unaffected first-cousin parents. Mjc0N2ExZGU4ZjA3ZTE0NWZmN2Q4MDY2N2Y1MmExMjFhNDIxMDAzMDU0ZTAx A review of the patients history will reveal atopy that can manifest as food allergies, severe pruritus, asthma, angioedema, and urticaria. Van der Velden et al. [PubMed: 11100033, related citations] Acral PSS: Transglutaminase 5 is crucial for normal epidermal differentiation. It is associated with atopic manifestations. Peeling skin syndrome localized to the acral surfaces represents a new variant. Donations are an important Dry Skin: The patients of peeling skin syndrome have reported to have extremely dry skin. Genet. Read on to learn whether it poses risks. Health Conditions. Type A PSS can be distinguished from these diseases by history, physical exam, and histopathologic analysis of skin biopsies (See expected results of diagnostic studies). Family history included 3 more affected individuals, but they were not available for study. A missense mutation in TGM5 causes acral peeling skin syndrome in a Tunisian family. A previously diagnosed case of Netherton syndrome with atypical clinical features and an absence of Spink5 mutations should be further worked up for type B PSS. Acral PSS is limited to the hands and feet, whereas generalized PSS results in widespread peeling. 1997;133:53536. Chm sc b bu; Dinh dng b bu; Chm sc sau sinh; Chm sc b; Dinh dng cho b; Sc khe. Wounds may heal less well. TGM5 mutations impact epidermal differentiation in acral peeling skin syndrome. ZGM4NDJiMWQ3OGE4NTA2NWM5MGRjYzQ2MzJiMGI5MzgzOTNlOWY2ZWUyZjU1 Peeling Skin Syndrome (PSS) is a rare disorder likely inherited in an autosomal recessive pattern with variable age of onset from birth to adulthood [ 1, 2 ]. Invest. Other differential diagnoses that clinically present in a similar way include keratolytic winter erythema, exfoliative ichthyosis, dermatophytosis, psoriasis, allergic contact dermatitis, and dyshidrotic eczema. https://medical-dictionary.thefreedictionary.com/acral+peeling+skin+syndrome, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Acral dysostosis with facial and genital abnormalities, acral inflammatory myxoinflammatory fibroblastic sarcoma. The patients had blisters and peeling of acral skin; healing occurred spontaneously, sometimes with residual erythema, burning sensation, or itching, but without scarring or atrophy. direct entry bsn programs near mysuru, karnataka. NDI4MTVlZTQ1Mzg2YmZiMDI2YzlkOGZlMDM1MzI3ZjFmYjk4MTk3MDgxYzVm A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. MeSH The term "acral" refers to the fact that the skin peeling in this condition is most apparent on the hands and feet. This pathogenic overlap elucidates why aspects of the Netherton syndrome phenotype is similar to Type B PSS, including skin peeling, erythroderma, secondary skin infections, and atopic manifestations. See this image and copyright information in PMC. -, Shwayder T. Acral peeling skin syndrome. Disclaimer - the author PCDS cannot accept responsibility for any misleading or incorrect statements, and the management of individual patients remains the direct responsibility of the individual doctor. Generalized PSS is further subcategorized by the absence or presence of inflammation and includes generalized noninflammatory PSS (type A PSS) and generalized inflammatory PSS (type B PSS). [Full Text], Hashimoto, K., Hamzavi, I., Tanaka, K., Shwayder, T. - Drug Monographs (2012) noted that in contrast to the 2 Tunisian patients reported by Kharfi et al. The absence of corneodesmosin leads to impaired cell-to-cell adhesion in the upper dermis, resulting in desquamation of the stratum corneum. Photograph of both feet. Copyright 2022 Haymarket Media, Inc. All Rights Reserved. A missense mutation in TGM5 causes acral peeling skin syndrome in a Tunisian family. ZGU0YyJ9 Acral peeling skin syndrome is a very rare genetic condition that causes peeling of the skin on your hands and feet. Peeling usually affects your hands and feet but may also affect your arms or. hands peeling after virusmetal arms: glitch in the system characters YTYxOWMyZDdhZWQ5NmM1YmIwZTk2NTNiODY5NTE5NDAzMWUzMDFkZjQ2ZTA1 [3] Am. To ensure long-term funding for the OMIM project, we have diversified A recessive mutation in the CSTA gene has also been identified in a few cases that do not have the TGM5 mutation. Acral peeling skin syndrome (APSS) is an inheritable skin condition that causes painless peeling of the top layer of skin, typically on the hands or feet. A 34-year-old white man was referred to us for possible epidermolysis bullosa. "Acral" refers to the fact that the peeling of the skin is most noticeable on the hands and feet of this state. CSTA encodes for cystatin, a serine protease inhibitor that is expressed throughout the dermis. Acral peeling skin syndrome causes painless peeling of the top layer of your skin called the epidermis. A recurrent mutation in the TGM5 gene in European patients with acral peeling skin syndrome. Some studies have shown that elevated kallikrein and histamine levels also partially contribute to the increased turnover and desquamation of the stratum corneum found in this disease. Only a few reports of. Three types of PSS have been characterized based on the areas of skin affected, presence of systemic manifestations, and distinct genetic mutations. [Full Text], Kharfi, M., El Fekih, N., Ammar, D., Jaafoura, H., Schwonbeck, S., van Steensel, M. A. M., Fazaa, B., Kamoun, M. R., Fischer, J. Some researchers have hypothesized that antihistamines and kallikrein inhibitors may be helpful for this disease. Inflammatory/Type B PSS: Laboratory tests classically show evidence of atopy including eosinophilia and elevated IgE. and transmitted securely. ZWM4M2U4NjY4MTVjNDBiNDUzY2ZlMzBlYzI5OGEyMDMxZTg0YjkwMjJiYTNh The mutation was present on the same haplotype in the 2 kindreds, indicating a probable ancestral mutation. J Invest Dermatol. The site is secure. Latest News Your top articles for Thursday, Continuing Medical Education (CME/CE) Courses. Peeling may be induced by mechanical trauma, humidity, heat, perspiration, and exposure to water. Corneodesmosin is responsible for cell-to-cell adhesion in the upper dermis, and its degradation is essential for normal desquamation. Other symptoms can include easily plucked hairs and fragile skin. These entities can be distinguished from APSS by history, physical exam, and histopathologic analysis of skin biopsies (See Expected results of diagnostic studies above). 132: 2422-2429, 2012. Shwayder et al. Other families with a more widespread peeling skin phenotype similar to that described in PSS (270300) lacked TGM5 mutations. It is clinically manifested by erythema and pruritus due to release of histamine and other inflammatory mediators. Derm. component of our efforts to ensure long-term funding to provide you the Enjoying our content? Acral refers to the fact that the peeling is most apparent on the hands and feet, although peeling may also occur on the arms and legs. 2012 Jul;26(7):844-8. doi: 10.1111/j.1468-3083.2011.04166.x. Acral skin could be easily peeled with light rubbing, leaving tender, superficial erosions that usually healed within 2 to 3 days; however, peeling recurred in the same or adjacent areas. ZjliM2QwZDczMzg0YTg5YTVhMTdmOTc2MDA4MGIwZmVkYjk3YTZjZTkwYjQ4 8600 Rockville Pike Histologic changes in type B PSS show acanthosis and hypergranulosis. Patients should be educated about how scratching can lead to scarring and secondary complications. 2011 Mar;131(3):561-4. doi: 10.1038/jid.2010.434. There is also a single case report of a patient with type B PSS with recurrent infections and IgA nephropathy. J. Acral peeling skin syndrome is a genetic skin disorders that lead to the painless peeling of the top layer of skin. - Caused by mutation in the transglutaminase-5 gene (TGM5, Marla J. F. O'Neill - updated : 11/6/2014. Zjk1MjkyMDBlODMwMDFhOTE3MzkwZTQwY2I1ODZiM2RhYTdjMGUxM2YzNDM0 Peeling skin may occur because of direct damage to the skin, such as from sunburn or infection. Unable to load your collection due to an error, Unable to load your delegates due to an error. Acral peeling skin syndrome. Patients may complain of erythema, pruritus, or a burning sensation in the exposed denuded area. Histologic examination of the border of a palmar lesion showed a thickened stratum corneum with cleavage in the clear zone; ultrastructural studies showed enlarged intercellular spaces in the stratum corneum, with stellate and electron-dense keratohyalin granules of various sizes in the granular cells. Studies suggest that APSS is often misdiagnosed or underdiagnosed, and is more common than previously thought. It most commonly causes painless peeling of the top layers of skin on your hands and feet. While it typically manifests from early childhood, in this first reported case from South Africa, the patient did not manifest clinically until the fourth decade of life. (2010) concluded that APSS may resemble EBS in young individuals. Patients may have occasional pruritus but do not show any evidence of atopy, fever, systemic manifestations, or nail, hair, or mucous membrane abnormalities. Peeling usually affects your hands and feet but may also affect your arms or legs. Acral peeling skin syndrome Synonyms Peeling skin syndrome 2; Peeling skin syndrome, acral type (subtype) Modes of inheritance Autosomal recessive inheritance (Orphanet) Summary Excerpted from the GeneReview: Epidermolysis Bullosa Simplex Peeling skin syndrome (PSS) refers to a rare group of heterogeneous autosomal recessive diseases that manifest as superficial skin peeling without mucosal peeling. NTFhOWYyNDcwY2E2MjZlZDE2MTJjMDU1MThlMzgyNDQwZTk4ZjRjZDQ5MmQ1 At presentation, physical examination revealed ongoing exfoliation with new skin formation on the palms and soles. Genealogic research dating to the year 1650 revealed no consanguinity between the families. Arch. Patients may complain of pruritus in the denuded area. Bo him; Chm sc sc kho Background: Hypercalciuria in a child with acral peeling skin syndrome: a case report. ZjA4OWE1NzJjOGU5MDZlOGU3ZDI4ZmQ0M2RhNWU2NWJmN2ViN2E3NzM2ZDcw our revenue stream. Generalized noninflammatory/type A PSS: Type A PSS presents with superficial peeling of skin shortly after birth or in early childhood. Over 90% Epub 2011 Jun 29. The crosslinking of structural proteins between these two layers stabilizes their attachment and the loss of this enzyme leads to instability. For healthcare providers, laboratory testing sites can be found in the GTR through NCBI. SNOMEDCT: 709416009; In 2 Tunisian brothers with APSS, Kharfi et al. Description Collapse Section Acral peeling skin syndrome is a skin disorder characterized by painless peeling of the top layer of skin. Generalized noninflammatory/type A PSS: Type A PSS is due to a mutation in the CHST8 gene that encodes golgi transmembrane N-Acetylgalactosamine-4-O-sulfotransferase (GalNAc4ST1). Genealogic analysis established consanguinity dating to the 1780s. Generalized inflammatory/Type B PSS: Type B PSS is due to a mutation in the corneodesmosin gene (CDSN). (2005) described 2 families, 1 Dutch and 1 Scottish, with noninflammatory acral peeling skin syndrome in which peeling was accompanied by erythema. Most of the mutations change single protein building blocks . These. In 6 unrelated children and 1 adult patient from Germany, 1 child from Sweden, and 1 child from Finland with blistering and peeling acral skin that was initially diagnosed as epidermolysis bullosa simplex and who were negative for mutations in KRT5 (148040) and KRT14 (148066), Kiritsi et al. Am. Cassidy et al. - Full-Length Features J Am Acad Dermatol. There is no cure for acral peeling skin syndrome . Refer to the chapter Peeling skin conditions. The three identified forms of peeling skin syndrome are all rare autosomal recessive disorders. Answer. Acral PSS: Patients present with spontaneous or continuous superficial peeling and blistering on the volar and dorsal surfaces of hands and feet. This syndrome is caused by a homozygous missense mutation in the CHST8 gene, leading to an amino acid substitution in the protein. Generalized inflammatory/Type B PSS: Patients present with patchy and widespread peeling of the skin with erythema and pruritus. Kse O, Safali M, Ko E, Arca E, Aikgz G, zmen I, Yeniay Y. J Eur Acad Dermatol Venereol. The authors also noted that in 3 families, vertical transmission of disease was considered, because either parents or offspring were reported to have had skin blistering in childhood; however, clinical examination of the putative affected heterozygotes was not reported. This condition is very rare, and a person's biological parents must each carry a copy of the gene mutation for a person to show any symptoms. A number sign (#) is used with this entry because of evidence that peeling skin syndrome-2 (PSS2), an acral form of the disorder, is caused by homozygous or compound heterozygous mutation in the TGM5 gene (603805) on chromosome 15q15. Acral peeling skin syndrome is a rare autosomal recessive disorder in which skin exfoliation is limited to the hands and feet. Acral peeling skin syndrome is a very rare genetic skin condition. A. J., Jonkman, M. F., McLean, W. H. I., Hamm, H., Steijlen, P. M., van Steensel, M. A. M., van Geel, M. Other findings may include blistering and/or reddening of the skin (erythema) and itching (pruritus). The first episode occurred 4 years prior, followed by perennial skin peeling during the spring seasons. (Letter) The main symptom is continual peeling of the skin. J Invest Dermatol. [PubMed: 19440220] These patients represented a localized variant of peeling skin syndrome and Ultrastructural examination revealed increased intercellular lipids and abnormal, "moth-eaten," keratohyalin granules, but the authors were unable to determine whether the initiated within the horny cells or between adjacent cells. Peeling skin syndromes (PSSs) are a heterogeneous group of rare, autosomal recessive disorders characterized by superficial, painless peeling and blistering of the skin without mucosal fragility [ 1-3 ]. Sweating, heat, humidity, or mechanical trauma aggravated symptoms. Genetic disease, including a rare skin disorder called acral peeling skin syndrome that causes painless peeling of the top layer of skin Specific diseases and conditions that can cause peeling skin include: Athlete's foot Atopic dermatitis (eczema) Contact dermatitis Dry skin Jock itch Kawasaki disease Medication side effects Non-Hodgkin's lymphoma Kiritsi et al. This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. The peeling skin is usually painless. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. review the literature and organize it to facilitate your work. Electron microscopy shows intracellular and intercellular cleavage of corneocytes. Aggressive clinical awareness is warranted as PSS is commonly misdiagnosed. science writers and biocurators.
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