Unless expressly stated otherwise, nothing in this Announcement (including any statement of estimated synergies) is intended as a profit forecast or estimate for any period and no statement in this Announcement should be interpreted to mean that earnings or earnings per share or dividend per share for Takeda or Shire, as appropriate, for the current or future financial years would necessarily match or exceed the historical published earnings or earnings per share or dividend per share for Takeda or Shire, as appropriate. Copyright 1995-2022 Takeda Pharmaceutical Company Limited. This makes Takeda one of the top ten pharmaceutical companies in the world. As a result of those discussions, Takeda has offered commitments to divest SHP647 and certain associated rights, with a view to the EC granting a Phase I conditional clearance for the Acquisition and not initiating proceedings under Article 6(1)(c) of Council Regulation (EC) 139/2004. We are looking forward to the benefits this combination will bring to patients worldwide, the opportunities it will bring for our employees and the returns it will deliver for our shareholders., Susan Kilsby, chairman of Shire, said, Over the last 30 years, Shire has become the global leader in treating rare diseases, delivering innovative products that transform patients lives. Takeda Announces Publication of Circular and Notice of Extraordinary General Meeting of Shareholders in relation to the Proposed Acquisition of Shire, Global Ethics & Compliance / Global Code of Conduct, Notice of the Resolution of the Date and Agenda of the Extraordinary General Meeting of Shareholders. Although it is believed that the expectations reflected in such forward-looking statements are reasonable, no assurance can be given that such expectations will prove to have been correct and you are therefore cautioned not to place undue reliance on these forward-looking statements which speak only as at the date of this Announcement.Additional risk factors that may affect future results are contained in Shires most recent Annual Report on Form 10-K and in Shires subsequent Quarterly Reports on Form 10-Q, in each case including those risks outlined in ITEM1A: Risk Factors, and in Shires subsequent reports on Form 8-K and other Securities and Exchange Commission filings (available at www.Shire.com and www.sec.gov), the contents of which are not incorporated by reference into, nor do they form part of, this Announcement. For more information, visit https://www.takeda.com/newsroom/.Important NoticeThis announcement is not intended to, and does not, constitute, represent or form part of any offer, invitation or solicitation of an offer to purchase, otherwise acquire, subscribe for, sell or otherwise dispose of, any securities whether pursuant to this announcement or otherwise.The distribution of this announcement in jurisdictions outside the United Kingdom or Japan may be restricted by law or regulation and therefore any person who comes into possession of this announcement should inform themselves about, and comply with, such restrictions. Takeda's policy in the allocation of capital is as follows: In respect of Invest in growth drivers, Takeda makes disciplined and focused investments in value-creating business opportunities including R&D, new product launches, including in China, and plasma-derived therapies. Additional risk factors that may affect future results are contained in Shires most recent Annual Report on Form 10-K and in Shires subsequent Quarterly Reports on Form 10-Q, in each case including those risks outlined in ITEM1A: Risk Factors, and in Shires subsequent reports on Form 8-K and other Securities and Exchange Commission filings (available at www.Shire.com and www.sec.gov), the contents of which are not incorporated by reference into, nor do they form part of, this Announcement. OSAKA, Japan--(BUSINESS WIRE)-- NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTIONTakeda Pharmaceutical Company Limited (the "Company or "Takeda") announces that it has today, December 3, 2018 (London time), entered into a Loan Agreement with . -In June 2022, Takeda announced that TAK-003 demonstrated continued protection against dengue fever through four and a half years (54 months), with no important safety risks identified, in the . The company is confident that it will retain its investment grade credit rating and return to a net debt to EBITDA ratio of 2.0x or less within three to five years following completion.Weber will present at the J.P. Morgan Healthcare Conference at 3:30 p.m. PST on January 8, 2019.Notice regarding the Acquisition of the Entire Issued and To Be Issued Share of Shire plc. Earlier the same day, Takeda's shareholders. Therapeutic focuses of Takeda-Shire This marks the completion of the intended refinancing program for our bridge facility at an overall blended interest rate across the various components of the refinancing that is highly satisfactory, which we believe supports our intention to maintain our well-established dividend policy and investment grade credit rating. TAKEDA LIFE THEATER, Embark on a journey of discovery inside the human body! Takeda's acquisition is unusual. Although Shire is. With a truly innovative portfolio and pipeline,I believe thatthecombinationof the two companies is in the best interests of shareholders and offers an opportunity to improve the lives of even more patients globally with rare and highly specialized conditions., Brings together complementary positions in GI and neuroscience; provides leading positions in rare diseases and plasma-derived therapies to complement strength in oncology and focused efforts in vaccines. Kana Inagaki in Tokyo. The acquisition of Shire will provide compelling financial benefits for the combined group. 01.09.2019 Takeda CEO Optimistic About Growth Prospects as Drugmaker Finalizes Shire Takeover Source: FirstWord Takeda announced that it has completed its $62-billion acquisition of Shire. Creates a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, with an attractive geographic footprint and provides the scale to drive future development. An Opening Position Disclosure must contain details of the person's interests and short positions in, and rights to subscribe for, any relevant securities of each of (i) the offeree company and (ii) any securities exchange offeror(s). Combining this with Takedas early development and research-oriented R&D program will result in a highly complementary, robust, modality-diverse pipeline and a strengthened R&D engine focused on breakthrough innovation. Takeda is committed to addressing the worlds biggest challenges to sustainable development over the long term. Our employees are committed to improving quality of life for patients and to working with our partners in healthcare in approximately 80 countries. Under the terms of the acquisition, each Shire shareholder will be entitled to receive $30.33 in cash for each Shire share and either 0.839 new Takeda shares or 1.678 Takeda ADSs. Takeda conducts R&D both internally and with partners to stay at the leading edge of innovation. In addition, Takedas vaccine business will continue to address the worlds most pressing public health needs. Celebrating the grand opening of Takeda Global Headquarters. Nomination Committee and Compensation Committee, Audit and Supervisory Committee and Internal Audit, We will become a global, values-based, R&D-driven, biopharmaceutical leader, Supplier Registration Process via Ariba Commerce Cloud. In addition, Takedas vaccine business will continue to address the worlds most pressing public health needs. All rights reserved. Please note that the Acquisition remains subject to certain conditions, including approval by the shareholders of both companies. December 3, 2018 (London time) --- Takeda Pharmaceutical Company Limited (TSE:4502)(the Company or Takeda) announces that it has today, December 3, 2018 (London time), entered into a Loan Agreement with the Japan Bank for International Cooperation ( JBIC) for an aggregate principal amount of up to 3,700,000,000 U.S. dollars (the JBIC Loan). Proposed Acquisition of Shire plc by Takeda, Highly Compelling Strategic and Financial Rationale, Global Ethics & Compliance / Global Code of Conduct, https://www.takeda.com/investors/offer-for-shire/, Brings together complementary positions in gastroenterology (GI) and neuroscience; provides leading positions in rare diseases and plasma-derived therapies to complement strength in oncology and focused efforts in vaccines, Enhances Takedas cash flow profile, with management confident of delivering substantial annual cost synergies and generating attractive returns for shareholders, Takedas transformation positions the combined group to successfully integrate Shire and maximize value from the combination, 48.17 per Shire share based on the closing price of 4,535 per Takeda share on May 2, 2018, and the exchange rates of : of 1:147.61 and :$ of 1:1.3546 on May 4, 2018 (being the latest practicable date prior to this announcement); and. Takedas R&D efforts are focused on its four therapeutic areas of Oncology, Gastroenterology (GI), Neuroscience and Rare Diseases, with targeted R&D investment also committed to Plasma-Derived Therapies (PDT) and Vaccines. Overall, Takeda made five public bids for Shire. It is not intended to and does not constitute, or form part of, an offer, invitation or the solicitation of an offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of any securities, or the solicitation of any vote or approval in any jurisdiction, pursuant to the acquisition or otherwise nor will there be any sale, issuance, exchange or transfer of securities of Shire or Takeda pursuant to the acquisition or otherwise in any jurisdiction in contravention of applicable law. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.For more information, visit https://www.takeda.com, Investor Relations Contact:Takashi Okubotakeda.ir.contact@takeda.com+81 3 3278 2306Media Inquiries:Tsuyoshi Tada (Outside of Japan)Tsuyoshi.Tada@takeda.com+1 617 551 2933Kazumi Kobayashi (Japan)Kazumi.kobayashi@takeda.com+81 3 3278 2095. The content of the website referred to in this announcement is not incorporated into and does not form part of this announcement.Disclosure requirements of the CodeUnder Rule 8.3(a) of the Code, any person who is interested in 1% or more of any class of relevant securities of an offeree company or of any securities exchange offeror (being any offeror other than an offeror in respect of which it has been announced that its offer is, or is likely to be, solely in cash) must make an Opening Position Disclosure following the commencement of the offer period and, if later, following the announcement in which any securities exchange offeror is first identified. Media and Investor Contacts:Takeda (Investor Relations)Takashi Okubotakeda.ir.contact@takeda.com+81 3 3278 2306Takeda (Media inside Japan)Kazumi Kobayashikazumi.kobayashi@takeda.com+81 3 3278 2095Takeda (Media outside Japan)Elissa JohnsenElissa.Johnsen@takeda.com+1 312 285 3203Tsuyoshi TadaTsuyoshi.Tada@takeda.com+1 617 551 2933About Takeda Pharmaceutical CompanyTakeda Pharmaceutical Company Limited (TSE: 4502) is a global, research and development-driven pharmaceutical company committed to bringing better health and a brighter future to patients by translating science into life-changing medicines. The content of the website referred to in this Announcement is not incorporated into and does not form part of this Announcement.Disclosure requirements of the CodeUnder Rule 8.3(a) of the Code, any person who is interested in 1% or more of any class of relevant securities of an offeree company or of any securities exchange offeror (being any offeror other than an offeror in respect of which it has been announced that its offer is, or is likely to be, solely in cash) must make an Opening Position Disclosure following the commencement of the offer period and, if later, following the announcement in which any securities exchange offeror is first identified. All statements other than statements of historical facts included in this Announcement may be forward looking statements. Countless innovations. The Acquisition will also create a highly complementary, modality-diverse pipeline and a strengthened R&D engine focused on breakthrough innovation. Takeda intends to maintain its investment grade credit rating with a target net debt to Adjusted EBITDA ratio of 2.0x or less within three to five years following completion of the Acquisition, without the need to issue new shares. Under the terms of the acquisition, Shire shareholders will be entitled to receive, for each Shire share, $30.33 in cash and either 0.839 new Takeda shares or 1.678 Takeda ADSs. The integrated company will continue to be headquartered in Japan, expand its R&D presence in the Boston area and have major regional locations in Japan, Singapore, Switzerland and the U.S. Innovative products, especially in oncology and gastroenterology, as well as Takedas presence in emerging markets, are currently fueling the growth of Takeda. It will be significantly accretive to underlying earnings per share from the first full fiscal year following completion, and will produce strong combined cash flows. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof. It's getting hard to keep track of the bad news about the news right now. SHPG announced that its acquisition by Japan-based Takeda Pharmaceuticals for $62 billion has been approved by its shareholders. Takeda will continue to focus on the acceleration of its oncology business, following its recent acquisition of ARIAD Pharmaceuticals. The deal was sanctioned by the Royal Court of Jersey in early January 2019; the acquisition was closed on 8 January, and integration of the two companies could begin. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof. Takeda Pharmaceutical Company Limited recently announced the completion of its acquisition of Shire plc on January 8, 2019. The EGM is to be convened at 10:00 a.m. on December 5, 2018 at INTEX Osaka, Hall 6B Zone. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takedas global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takedas operations and the timing of any such divestment(s); and other factors identified in Takedas most recent Annual Report on Form 20-F and Takedas other reports filed with the U.S. Securities and Exchange Commission, available on Takedas website at:https://www.takeda.com/investors/reports/sec-filings/oratwww.sec.gov. Takeda (Investor Relations)Takashi Okubotakeda.ir.contact@takeda.com+81 3 3278 2306Takeda (Media inside Japan)Kazumi KobayashiKazumi.Kobayashi@takeda.com+81 3 3278 2095Takeda (Media outside Japan)Tsuyoshi TadaTsuyoshi.Tada@takeda.com+1 617 551 2933Elissa JohnsenElissa.Johnsen@takeda.com+1 312 285 3203Finsbury (communications support to Takeda)(U.K.) Rollo Head / James Murgatroyd / Anjali Unnikrishnan+44 207 251 3801(U.S.) Kal Goldberg / Chris Ryall+1 646 805 2000About Takeda Pharmaceutical CompanyTakeda Pharmaceutical Company Limited (TSE: 4502) is a global, research and development-driven pharmaceutical company committed to bringing better health and a brighter future to patients by translating science into life-changing medicines. Nomination Committee and Compensation Committee, Audit and Supervisory Committee and Internal Audit, We will become a global, values-based, R&D-driven, biopharmaceutical leader, Supplier Registration Process via Ariba Commerce Cloud. Takeda Announces Execution of Loan Agreement in Connection with Proposed Acquisition of Shire plc . Takeda has completed its 46 billion-acquisition of Shire, a deal that took just eight months to see through from announcement to close. Upon completion, the new Takeda shares will be listed on the Tokyo Stock Exchange, and local Japanese stock exchanges. Acquisition Of Shire The total deal is consistent with Takeda's fifth proposal and values Dublin-based Shire at 49.01 pounds, or about $66.21, per share. Takeda announced acquisition of Shire Plca rare drug specialist and a long-time rivalon May 8, 2018marking the largest bet of the year. The JBIC Loan will finance a portion of the funds necessary for the acquisition of Shire plc (Shire) (the Acquisition) and reduce commitments under the 364-Day Bridge Credit Agreement entered into in connection with the Acquisition on May 8, 2018 (as amended on June 8, 2018 and October 26, 2018) (the Bridge Credit Agreement).We are pleased to have secured this loan from JBIC, an organization which promotes the maintenance and strengthening of the international competitiveness of Japanese industries, said Costa Saroukos, Chief Financial Officer of Takeda. By their nature, forward-looking statements involve risk and uncertainty, because they relate to events and depend on circumstances that will occur in the future and the factors described in the context of such forward-looking statements in this Announcement could cause actual results and developments to differ materially from those expressed in or implied by such forward-looking statements. With the date of our Extraordinary General Meeting of Shareholders now set, we are looking forward to continuing our dialogue with shareholders regarding the compelling strategic and financial benefits of this transaction.Further to the announcement on October 26, 2018, Takeda and Shire have held discussions with the European Commission (EC) in relation to the future potential overlap in the area of inflammatory bowel disease between Takedas marketed product Entyvio (vedolizumab) and Shires pipeline compound SHP647, which is currently in Phase III clinical trials. For more information, visit https://www.takeda.com/newsroom/.Additional InformationThis Announcement is provided for information purposes only. The acquisition is expected to close in the first half of calendar year 2019. Following completion of the Acquisition, Takeda will continue to focus on the acceleration of its oncology business, following its recent acquisition of ARIAD Pharmaceuticals. The acquisition will build on Takedas long Japanese heritage and values-based culture to create a global biopharmaceutical leader, driven by innovative and world-class R&D. Approximately 30,000 Takeda employees are committed to improving quality of life for patients, working with Takeda's partners in health care in more than 70 countries. The transaction is also expected to result in attractive returns for shareholders, with the return on invested capital (ROIC) expected to exceed Takedas cost of capital within the first full fiscal year following completion. Together, the combined group will have leading positions in two of the largest drug markets globally: the U.S. and Japan. One vision. Shire investors will receive $30.33 in cash and either 0.839 new Takeda shares or 1.678 Takeda American depositary shares for each share, valuing the offer at 48.17 pounds a share based on. Shire (acquired by Takeda) 20183 - 2019111 County Dublin, Ireland (Shire was acquired by Takeda in Jan 2019) Re-built Shire Treasury team in Ireland hiring Capital Market and Risk. Celebrating the grand opening of Takeda Global Headquarters. Except to the extent otherwise required by applicable law, neither Takeda nor Shire undertake any obligation to update or revise forward-looking statements, whether as a result of new information, future events or otherwise.No profit forecasts or estimatesUnless expressly stated otherwise, nothing in this Announcement (including any statement of estimated synergies) is intended as a profit forecast or estimate for any period and no statement in this Announcement should be interpreted to mean that earnings or earnings per share or dividend per share for Takeda or Shire, as appropriate, for the current or future financial years would necessarily match or exceed the historical published earnings or earnings per share or dividend per share for Takeda or Shire, as appropriate.Medical informationThis Announcement contains information about products that may not be available and in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. I am confident that this relentless focus will enable us to continue delivering against our priorities throughout this process. For more information, the full Rule 2.7 announcement setting out full details of the offer to Shire shareholders is available at: https://www.takeda.com/investors/offer-for-shire/. Takeda will host a transaction conference call at 4.15pm 5pm JST / 8.15am 9am BST / 3.15am 4am EST on May 8, 2018 to discuss the transaction. OSAKA, Japan--(BUSINESS WIRE)-- Further to the announcement on May 8, 2018, by Takeda Pharmaceutical Company Limited ("Takeda" or the "Company") regarding the proposed acquisition (the "Acquisition") of Shire plc ("Shire"), Takeda announces the publication of a circular (the "Circular") containing a notice of its decision to hold an Extraordinary General Meeting of . One vision. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs, including the ones under development.Publication on WebsiteIn accordance with Rule 26.1 of the Code, a copy of this Announcement will be made available (subject to certain restrictions relating to persons resident in restricted jurisdictions) on Takeda's website at www.takeda.com/investors/offer-for-shire by no later than 12 noon (London time) on November 13, 2018. Find the original press release here. Media Contacts:Japanese MediaRyoko Matsumotoryoko.matsumoto@takeda.com+81 (0) 3-3278-2037, Media Outside JapanChristina Beckermanchristina.beckerman@takeda.com+1 781-482-0831. In addition, Shires portfolio will benefit from Takedas strong international presence in emerging markets and Japan. These expressions are also used where no useful purpose is served by identifying the particular company or companies. 49.01 per Shire share based on the closing price of 4,923 per Takeda Share and the exchange rates of : of 1:151.51 and :$ of 1:1.3945 on April 23, 2018 (being the day prior to the announcement that the Shire board would, in principle, be willing to recommend the consideration). Impact on the financial results for the fiscal year ending March 2019Upon the execution of the JBIC Loan, the commitments under the Bridge Credit Agreement will be reduced by 3,700,000,000 U.S. dollars. Copyright 1995-2022 Takeda Pharmaceutical Company Limited. OSAKA, Japan, October 28, 2021--Takeda Pharmaceutical Company Limited (TOKYO:4502/NYSE:TAK) ("Takeda") announced that its Board of Directors resolved today to engage in the acquisition of its own . Takeda Pharmaceutical Company Limited ( TSE:4502) (the " Company or " Takeda ") announces that it has today, December 3, 2018 (London time), entered into a Loan Agreement with the Japan Bank. We appreciate the support of our employees, partners and shareholders throughout the process. Celebrating the grand opening of Takeda Global Headquarters. osaka, japan, october 28, 2021 - takeda pharmaceutical company limited (tse:4502/nyse:tak) ("takeda") announced that its board of directors resolved today to engage in the acquisition of its own shares pursuant to the provision of its articles of incorporation in accordance with article 459, paragraph 1 of the companies act of japan, as detailed Likewise, the words we, us and our are also used to refer to subsidiaries in general or to those who work for them. Upon the closing of the transaction, Takeda shareholders will own approximately 50 percent of the combined group. 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