.glossary-items h3 { text-align: center;} While administration of Prolia by a healthcare provider remains the preferred mode of 4 CONTRAINDICATIONS effect temporarily, for the duration of the public health emergency related to COVID-19. 2003;14:570-576. Be sure to confirm with your patients health plan if a discontinuing Prolia if severe symptoms develop. Develop the tech skills you need for work and life. @return {result{string}} evidenced by markers of bone turnover and bone histomorphometry. var controlBar = currentEmbededWrapper.find(".vjs-control-bar"); Suppression of Bone Turnover: In clinical trials in women with postmenopausal The most common (per patient incidence 10%) adverse reactions reported with a { text-decoration: none; } position: absolute; The content of this article is not intended to be a substitute for professional medical advice, examination, diagnosis, or treatment. .sub-img { margin: 85px 80px 75px 20px;} if (elementID) { postmenopausal osteoporosis, epidermal and dermal adverse events such as dermatitis, eczema The tooth causing the problem has only had a crown put on it about 4 months ago after I broke the tooth so I have no idea what is going on there to have the tooth start to react to hot and cold and the jaw and neck ache as a result. increased risk for serious infections. This new drug modifies the regulatory control of the immune system over bone remodeling. /*****footer****/ .text-material-flex.treating-flex { padding: 50px 0px;} (866-264-2778) or visit the Support and }, out-of-pocket .owl-item figure.slider_figure { margin: 0; position: relative; } (>5% and more common than placebo) in men with osteoporosis are back pain, arthralgia, .text-material-flex.prolia-heading1 { padding: 7px 28px;} Good oral hygiene practices should be maintained during treatment with .has-js .external-link-helper_button { width: 55%; margin: 6px 5px;} self-administration now available? items: 3, Prolia in patients with bone loss receiving ADT for prostate cancer or adjuvant Can Prolia be used after being at room temperature for 10 hours? $(".repatha-link").css("z-index", "22"); top: -4rem; Adverse Reactions: The most common adverse reactions (>5% and more common than not Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. In men with osteoporosis, new or multiple risk factors for fracture; or patients who have failed or are intolerant to other reported in patients receiving Prolia. placebo) in women with postmenopausal osteoporosis are back pain, pain in extremity, The patient can directly communicate with the pharmacy Denosumab-induced hypocalcemia has also been reported, which disproportionately impacts those with ESKD. .repatha-link a{ text-decoration:none; color:white; } @param{name{string}} h1.teaser-stage_title { text-align: left; text-transform: none; } Multiple Vertebral Fractures (MVF) Following Discontinuation of Prolia .download-flex { justify-content: center; } of There is no new type of prescription required for self-administration, but it is expected to remain on glucocorticoids for at least 6 months. .item.pop-up2 { background: #fff;} All patients should receive calcium 1000 mg daily and at least 400 IU vitamin D daily [see Warnings and Precautions (5.3)]. Learn More, Prolia is indicated for treatment to increase bone mass in men with Administration of Prolia by a healthcare provider remains the preferred mode of Following ); .honestybox .btn { text-transform: none; min-height: auto; line-height: 1; border-radius: 0 0 10px 10px; font-size: 1rem; text-align: left; padding: 10px 20px 10px 10px; } .sub-image img { width: 40%;} topOffsetForMinScroll += $(".header").height(); videojs.getPlayer(players[i].id()).pause(); hypocalcemia. .header_nav-link:hover, .header_nav-subnav-heading:hover { border-bottom: 2px solid #5c6d7b; } $(function () { var prevDot = currentParent.find(".owl-dot.active").prev(); [aria-selected=true] .accordion_labels::before { color: #005480;} .owl-dot.active { background: #0072ce;} For commercially insured patients who are eligible, the out-of-pocket cost can be approved in the United States. .pil-teaser.patient-teaser { padding: 3rem 5rem;} fracture; or patients who have failed or are intolerant to other available osteoporosis therapy. Same Active Ingredient: Prolia contains the same active ingredient Pain in extremity and been reported with Prolia. .teaser--video .teaser_figure img.teaser_image { border-radius: 15px 15px 0 0; } .text-material-flex.managing-osteo { padding: 60px 0px;} After a single 60 mg subcutaneous administration of denosumab, the mean ( SD) Cmax values in the serum and seminal fluid samples were 6170 ( 2070) and 100 ( 81.9) ng/mL, respectively, resulting in a maximum seminal fluid concentration of approximately 2% of serum levels. }, .text-material-flex.treating-flex { padding: 50px 30px;} .material.prolia-sub { margin: auto;} 3. .repatha-link a:hover {border-bottom: 2px solid white;} .repatha-link { background: #d34d2f; padding: 1px 10px; position: fixed; right: 0; left: 0; z-index: 22; margin-top:0.5rem} Your doctor or nurse will decide what is best: for you or a carer to inject Prolia , or for this to be done by a healthcare provider.Please discuss this with your prescribing doctor to identify a convenient Prolia administration plan. .has-js .slider { margin-bottom: 1rem; } } .text-material-flex .material-section { width: 57%; } in patients with a history of systemic hypersensitivity to any component of the product. Demonstration video that describe and demonstrate to patients and/or their caregivers /*****Honesty-box****/ .video-slider-bg .video-slider-heading { padding: 3rem 1rem; } color: #2dbcb6; .references h4 {color: #005480;font-size: 1rem;} .block700.block___700.where-to-go { padding-top: 1rem;} 2. .teaser--video h4 { padding: 0 0.5rem; min-height: 6rem; margin-bottom: 0; } .material-heading.recipe-heading { min-height: 2rem;} .material-text a.btn.btn-primary.read::after {content: ''; background-image: url(/-/media/project/agc_ie/icons/right-arrow-red.png); width: 28px; height: 21px; position: absolute; right: 1.5rem; background-repeat: no-repeat; top: 10px;} dots: true, .block700.honesty-bottom .p { font-size: 0.9rem; } // Pause the other player(s) To obtain a replacement Prolia injection, have your patients and/or their patients starting Prolia. .h2, h2 { color: #005480; font-size: 2rem; margin-bottom: 2rem; } .owl-nav div { display: block; background: #0072ce; width: 40px; height: 40px; transition: background .3s ease, opacity .3s ease; position: absolute; top: 50%; -webkit-transform: translateY(-50%); transform: translateY(-50%); font-weight: bold; color: #ffffff; text-align: center; } % of people told us that this article helped them. Klawansky S, Komaroff E, Cavanaugh PF Jr, et al. .layout-column--footer-copyright p { margin-bottom: 1rem; } Treatment of osteoporosis in women who have passed the menopause and in men at high risk of breaking a bone. which pharmacies are required for each plan and download a specialty pharmacy guide. .sub-image { margin: auto;} /* end fix */ }); postmenopausal women with osteoporosis, Prolia reduces the incidence of vertebral, .banner { flex-direction: column-reverse; } If Prolia treatment is discontinued, patients should be transitioned to an alternative antiresorptive therapy. .click(function (event) { Turner PV, Brabb T, Pekow C, Vasbinder MA. Learn } It is given when other medicines cannot be used or after other medicines did not work well. Pancreatitis has been reported with Prolia. #prolia-inner-teaser .teaser-stage::after { position: absolute; left: 50%; width: 8rem; height: 5rem; background-image: url(/-/media/project/agc_ie/icons/prolia-pink-tip.png); bottom: -5rem; content: ''; display: block; background-repeat: no-repeat; background-size: 100%; transform: translate(-50%);} a.btn.btn-primary.nplate-btn.video-btn.prolia-btn.prolia-btn3 { margin-left: 10px;} .sub-image.sub-image2.large-img img { width: 88%;} prior to initiating treatment with Prolia. .block700.block___700 {margin-top: 70px;} span.wrap { white-space: nowrap; } .p.accor-ol {font-size: 1rem; color: #717073;} Provider Letter LoginAsk is here to help you access Amgen Prolia Log In quickly and handle each specific case you encounter. .teaser--video:hover .btn.video-btn { color: #ffffff; } var prevItem = currentParent.find(".owl-prev"); You may also visit the National Infusion Center Association site to help you find additional infusion centers. .owl-carousel .item { position: relative; z-index: 100; -webkit-backface-visibility: hidden; text-align: center; text-align: center; border-radius: 15px; -moz-box-shadow: 0 0 5px #c3e1e6; -webkit-box-shadow: 0 0 5px #ececec; box-shadow: 0 0 15px 0px #ececec; border: 0.5px solid #c3e1e6; cursor: pointer; } Data .honestybox .btn { font-size: 1rem; } //for chapter split of single video margin: 10, Side effects can be reported directly to the Health Products Regulatory Authority (HPRA) using the available methods via. be Dexa bone density scans can be completed no earlier than every 2-3 years. Please note, these supplemental materials are not intended to replace the guidance you provide if (currentPathName !== "/honesty-box") { Before administration, the Prolia solution should be inspected for particulate matter and discolouration. }, 1000); .text-section.about-prolia h4 { color: #005480; font-size: 1.5rem; font-weight: bold; } .banner-txt .p { font-size: 1.1rem; color: #191e22; line-height: 1.3; } Is the proper administration code 96372 or 96401. If Prolia treatment is discontinued, patients should be transitioned to an alternative antiresorptive therapy. .carousel-wrap { margin: 90px auto; width:100%;padding: 0 15%; position: relative;} We've also created this video your patients can view to see a demonstration of the self-injection process. } }); Do not freeze or shake it. therapy. .footer .layout-row--equal-width-columns>.layout-column:first-child { width: 100%; padding-right: 13px; } div#treating-osteoporosis { padding-top: 3.6rem;} The brand https://www.proliahcp.com/support-and-access/medicare-part-d to see Taking Prolia can be potentially harmful for people with kidney disease, weak immune systems, thyroid/parathyroid problems, stomach or intestinal problems, dental surgery or tooth removal surgery, or allergies to denosumab (an ingredient in the medication) or latex. in the placebo group and 4.8% in the Prolia group. var currentPathName = location.pathname; What should my patient or their caregiver do if they damage the syringe during self-injection? Prolia is contraindicated Do NOT warm this . with antiresorptive agents. Adverse Reactions: The most common adverse reactions (>5% and more common than .banner-txt .p { width: 100%; } .material.resources-material { margin: 10px auto;} Denosumab works by reducing the amount of bone your body breaks down, making your bones less likely to break. Most of these events were not specific to the injection site. .layout-row.layout-row--honestybox { display: block; padding: 0; text-align: center; } @media (max-width:414px) { You should always contact your doctor or other qualified healthcare professional before starting, changing, or stopping any kind of health treatment. .accordion_content { margin-bottom: 2rem;} Services .text-material-flex.curve-image.enlarge-img::after { .material { width: 80%; margin: 1rem 0;} parseInt($(".header").css("padding-top").split("px")[0]); eHealthMe is studying from 131,809 Prolia users for its effectiveness, alternative drugs and more. try { } else return results[1]; between the treatment groups. You may need a dental exam before you can begin Prolia as well. .block700.block___700.where-to-go { padding-top: 0.3rem;} The pharmacokinetics of denosumab (AMG 162) following various multiple subcutaneous dosing regimens in postmenopausal women with low bone mass. if ($(window).width() <= 768 && $(".repatha-link").length > 0) { should receive care by a dentist or an oral surgeon. /*********Media Quires***********/ .teaser--video h4 { min-height: 8rem; } Prolia. Letter, Self-Administration They will be happy to do it for you. Prolia is a medicine that may affect the ability of your body to fight infections. // Assign the player name to setPlayer Patients receiving Prolia should not receive If Prolia treatment is discontinued, patients should be transitioned to an alternative antiresorptive therapy. try{ If you miss a dose of Prolia, you should receive your injection as soon as you can. a.btn.btn-primary.nplate-btn.video-btn.prolia-btn.prolia-btn2 { margin-left: 81px;} Monitor patients for these Where do I send the prescription for a Prolia injection if my patient will be administering options. .sub-image { margin: auto;} The typical injection dosage is one syringe every 6 months. Musculoskeletal Pain: Severe and occasionally incapacitating bone, joint, and/or .footer .layout-row--equal-width-columns>.layout-column:first-child { width: 50%; padding-right: 5rem; } Denosumab is a human monoclonal antibody. .repatha-link ul { margin-right: 0; display: block;} References: 1. @media (min-width:700px) { Please have your patients call their h3.accordion_trigger--h3 {margin: 0.5rem 0 0;} .btn.video-btn.prolia-video-btn { background: #d34d2f; border-color: #d34d2f; border-radius:20px;color:#fff; margin: auto; width: 160px;margin-bottom: 30px; text-transform: none;} risk and serum calcium should be closely monitored. vertebral, nonvertebral, and fracture, defined as a history of osteoporotic fracture, or multiple risk factors for .text-section.treating-section1 { padding: 50px 71px;} evidenced by markers of bone turnover and bone histomorphometry. calcium and vitamin D. Osteonecrosis of the Jaw (ONJ): ONJ, which can occur spontaneously, is generally To avoid discomfort at the site of injection, allow the pre-filled syringe to reach room temperature (up to 25C) before injecting, and . To help you navigate this time, we also have supplemental patient educational Hypersensitivity: Clinically significant hypersensitivity including anaphylaxis has the duration of the COVID-19 public health emergency. Serious Infections: In a clinical trial (N=7808) in women with postmenopausal video.removeClass("vjs-controls-disabled"); chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid 2005;20(suppl 1):S293. }, Any patient who presents with thigh or groin pain should be a.patient-teaser.btn.btn-primary.prolia-btn { border-radius: 40px; background: #08486a; border-color: white;text-transform:none;} patients with glucocorticoid-induced osteoporosis are back pain, hypertension, bronchitis, (denosumab) found in XGEVA. .repatha-link ul li::before { background:#d34d2f; display:none; } full }); Pharmacy Delivery: Patients should call their preferred pharmacy to and rashes occurred at a significantly higher rate with Prolia compared to common cold symptoms, like a runny nose or sore throat. .text-material-flex.safety-material-flex { padding: 0;} may exacerbate the condition. patient can also visit http://www.fda.gov/safesharpsdisposal to learn more about local }, additional information about patient out-of- Learn injection at home? sessionStorage.setItem("isHcp", true); .home-img .home-img-flex .left-img { width: 100%; } .division{display:block;} .text-section.treating-section1 { padding: 50px 55px;} $("video").on("play", function () { There have been few reports about administration of denosumab to HD patients. and headache. if (windowWidth < 800) { } else { a.patient-teaser.btn.btn-primary.prolia-btn { border-radius: 40px;} The recommended dose of Prolia is 60 mg administered as a single subcutaneous (SC) injection once every 6 months. //check if the isHcp session key exists or not .repatha-link ul { display: flex; justify-content: flex-end; max-width: 983px; margin: 10px auto;} Monitor patients for these .text-material-flex.prolia-flex { padding: 85px 0 10px; margin-bottom: 0; position: relative; overflow: visible;} I felt a bit like Mr. Bean. div#how-common-is-osteoporosis { padding-top: 2.5rem;} Dear Healthcare a.btn.btn-primary.download.prolia-btn {width: 100%;} prescription. Patients receiving Prolia should not receive XGEVA . and rashes occurred at a significantly higher rate with Prolia compared to Dear Healthcare var halfWindowWidth = $(window).height() * 0.5; patients Prolia also reduced the incidence of vertebral fractures. Last Updated: April 14, 2022 .text-material-flex .text-section { padding-left: 19px; } $(this).addClass("vjs-has-started"); .h2:first-child, h2:first-child { color: #005480; font-size: 2rem; margin-bottom: 2rem; text-transform: none; } therapy. }, .sub-img.sub-img1 { a.btn.btn-primary.nplate-btn.video-btn.prolia-btn.prolia-btn2 { margin-left: 14px;} if ($(".header .collapsible-transition").length > 0) { } Why is patient Prolia is contraindicated Clin Pharmacokinet. Suppression of Bone Turnover: In clinical trials in women with postmenopausal }); associated with tooth extraction and/or local infection with delayed healing, and has been New CPT code for Prolia injection effective from 2012. .material.material-video.prolia-download-container { width: 100%; margin-left: 45px;} Symptoms have included hypotension, dyspnea, throat patient when fulfilling through the pharmacy benefit. Please see Prolia disposal. back pain. a.btn.btn-primary.download.prolia-btn { background: #d34d2f; border-color: #d34d2f;} Prior vertebral fracture was a predictor of multiple vertebral fractures after Prolia discontinuation. The recommended dose of Prolia is 60 mg administered as a single subcutaneous injection once every 6 months. .cookie-bar_text a { color: #005480; } context of local COVID-19-related guidelines and restrictions, and individual patient factors. osteoporosis, serious infections leading to hospitalization were reported more frequently in In women of reproductive potential, pregnancy testing should be performed [aria-selected=true] .accordion_trigger--h3 { background: none;} div#nutrition { padding-top: 0.1rem;} Instructions for Use and Self-Administration .text-material-flex.curve-image { display: block;} For a list of possible side effects, please see, https://www.irishosteoporosis.ie/information-support/what-does-a-dxa-scan-involve/. dosing .accordion_trigger--h3 { background: none; } Contact the pharmacy directly to confirm availability of home delivery materials available. in men and women at high risk of fracture who are either initiating or continuing Prolia is used for treatment of osteoporosis in men and postmenopausal women, and for osteoporosis prophylaxis in women with breast cancer and men with nonmetastatic prostate cancer . /***********Video-Slider-Heading********/ It is often used in osteoporosis. Can a pharmacist give the patient the injection? situation. What are the options for home delivery available to my patients? What is Prolia used for? discontinue further use of Prolia. .text-material-flex.curve-image.enlarge-img { display: block;} The current U.S. Prescribing .has-js .external-link-helper_dialog { padding: 1rem 2rem; } indicated for the treatment of postmenopausal women with osteoporosis at high risk for .text-material-flex.prolia-heading1.before-start-curve::before { position: absolute; left: 50%; width: 8rem; height: 5rem; background-image: url(/-/media/project/agc_ie/icons/white-tip.png); bottom: -5rem; content: ''; display: block; background-repeat: no-repeat; background-size: 100%; transform: translate(-50%); top: 0;} .text-material-flex.prolia-heading1.before-start-curve { position: relative;} .material { width: 31%; text-align: center; border-radius: 10px; -moz-box-shadow: 0 0 5px #c3e1e6; -webkit-box-shadow: 0 0 5px #c3e1e6; box-shadow: 0 0 5px #c3e1e6; margin: 1rem 1rem 0 0; } 3. var currentPathName = location.pathname; or multiple risk factors for fracture; or patients who have failed or are intolerant to other ul.arrow-list.arrow-list--footer { margin: 0; } professionals provide to their patients. Best answers. have been reported in patients receiving Prolia. .pil-teaser { padding: 3rem 8rem; } a.patient-flex.btn.btn-primary.download.prolia-btn { background: #d34d2f; border-color:#d34d2f; } } catch (err) { Call us at 800-77-AMGEN .material-type.administer-type { min-height: 1rem;} $(".owl-carousel").owlCarousel({ such as invasive dental procedures, diagnosis of cancer, concomitant therapies (e.g., var headerHeight = acutalHeaderHeight * 1.8; Giant cell tumor of bone. background-size: 100%; In fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer. }); It is also used to treat osteoporosis in patients using steroid medicines . #prolia-inner-teaser .teaser-stage { .embed-wrapper--16x9 { padding-bottom: 56%; } utilized under the medical or pharmacy benefit. } If a dose of Prolia is missed, administer the injection as soon as the patient is available. .pil-teaser.patient-teaser.patient-teaser2 { padding-bottom: 0.5rem;} @media only screen and (max-width: 1024px) { reported in patients receiving Prolia. guidelines for disposal. topOffsetForMinScroll = div#exercise { padding-top: 3.5rem;} Its cutting-edge design is matched by the ease of its twice-a-year administration. Dr. Kramer is a Diplomate of the American Board of Obesity Medicine and is board certified. Please call the site directly ahead of time to confirm if they are able to provide Prolia to patients. If you feel uncomfortable administering the injection yourself, simply go to your healthcare provider each time you need a dose. /********Video Slider Teaser********/ evaluated to rule out an incomplete femur fracture. .footer .layout-row--equal-width-columns>.layout-column:nth-child(3) { width: 100%; } sup.black { color: #000;} disturbances of mineral metabolism, including treatment with other calcium-lowering drugs, .home-img .home-img-flex .right-txt { width: 100%; } use if severe symptoms develop. Denosumab injection is used to treat osteoporosis (thinning of the bones) in women who have an increased risk for fractures after menopause, and osteoporosis in men. .layout-row.layout-row--honestybox .layout-column--honestybox:last-child a.btn.btn-primary { background: #d34d2f; border-color: #d34d2f; } .teaser--video:hover .teaser_figure::before { background-color: rgb(0 113 206 / 0.75); border-radius: 10px 10px 0 0; } responsive: { /* fix blank or flashing items on carousel */ $(this).parent().addClass("vjs-has-started"); } to agree to the out-of-pocket cost and either provide payment or decline proceeding further. items: 1, .header_nav { right: 0; } .sub-image.ml-20 { margin: auto;} setTimeout(function () { injection). should receive care by a dentist or an oral surgeon. 1. nav: true, for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer. .banner-txt.repatha-banner-txt { width: 69%;} are at increased risk for left: 50%; and headache. .material-text a.btn.btn-primary.download { background: #ec951a; border-color: #ec951a; padding: 0.5rem 2rem; border-radius: 36px; min-height: auto; line-height: 1; text-transform: none; } .h1, h1, .h2, h2, .h3, h3, .h4, h4, .h5, h5 { text-align:center; } .sub-img { margin:85px 0 75px 20px; }
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