1999 Sep;84(9):3316-21. doi: 10.1210/jcem.84.9.6009. Mol Cancer Ther. Drug Metab Pharmacokinet. Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases Label,2.It is marketed under the name Eliquis Label,3.Apixaban was 2006 Dec;5(12):993-6. The latter indication was presented by Pernix Therapeutics.12. [, Hartter S, Tybring G, Friedberg T, Weigmann H, Hiemke C: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. [, Park MS, Okochi H, Benet LZ: Is Ciprofloxacin a Substrate of P-glycoprotein? 1975 Jun 14;112(13 Spec No):63-6. Mechanism of action. 1999 Mar;16(3):408-14. Build, train, & validate predictive machine-learning models with structured datasets. 2007;67(3):247-52.
Epub 2015 Aug 28. ASA has been studied in recent years to determine its effect on the prevention of various malignancies 15. 2006 Dec;5(12):993-6. Generic Name Apixaban DrugBank Accession Number DB06605 Background. J Biol Chem. 3,4 Mechanism of action Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes. Axitinib: Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. 1984 Jul;230(1):94-102. Acetylsalicylic acid may increase the antiplatelet activities of Abciximab. 2007 May;50(6):791-9.
Mechanism Mol Pharmacol. Neuroscience. 2002 Jul;19(7):1034-7. Epub 2006 Mar 31. The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Acemetacin. 2007 Sep-Oct;28(5):722-6. Generic Name Apixaban DrugBank Accession Number DB06605 Background. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. 2009 May 20;122(10):1147-53.
Nasdaq [, Zhang Z, Meier KE: New assignments for multitasking signal transduction inhibitors. Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. [, Ai G, Dachineni R, Muley P, Tummala H, Bhat GJ: Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention. [, VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. [, Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity.
Mechanism Antipruritics, Incl. 2015 Apr;30(3):176-80. doi: 10.1016/j.nrl.2014.08.004. pii: ijms22137071. Drug Metab Dispos. For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. 2006 Sep;20(3):337-53. Mol Med Rep. 2013 Nov;8(5):1465-71. doi: 10.3892/mmr.2013.1676. [, Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR: Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. This reaction requires the hydroquinone (reduced) form of K3, menadiol, produced by an unidentified enzyme. [, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? 2006 Aug;123(3):294-305. Biochemistry. Mol Pharmacol.
Mechanism 2003 Mar;73(3):264-71. doi: 10.1067/mcp.2003.14. Avoid life-threatening adverse drug events & improve clinical decision support. Prostaglandin E1 is known to be an extremely powerful fever-inducing agent Label. Absorption is generally rapid and complete following oral administration but absorption may be variable depending on the route, dosage form, and other factors including but not limited to the rate of tablet dissolution, gastric contents, gastric emptying time, and gastric pH Label. 2010 Aug;38(8):1371-80. doi: 10.1124/dmd.109.031302. Chronic ASA toxicity is frequently accompanied by atypical clinical presentations that may be similar to diabetic ketoacidosis, delirium, cerebrovascular accident (CVA), myocardial infarction (MI) or cardiac failure. 2005 Apr;144(7):908-18. Pharm Res. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. J Clin Endocrinol Metab.
Mechanism [, Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, Mirosevich J, Lee FY, Jove R: Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. 2007 Feb;32(2):140-50.
Artemether Pol J Pharmacol. J Clin Pharmacol. Azathioprine: The risk or severity of adverse effects can be increased when Cladribine is combined with Azathioprine. Mol Pharmacol. Epub 2014 Apr 12. Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). Inhibition of COX-1 results in the inhibition of platelet aggregation for about 7-10 days (average platelet lifespan). Antihistamines, Anesthetics, Etc. 2011 Mar;4(1):1-9. doi: 10.1111/j.1753-5174.2010.00032.x. Tumour Biol. Biopharm Drug Dispos. [, Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS: Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. Generic Name Fluoxetine DrugBank Accession Number DB00472 Background. J Neurotrauma. The presence of this genotype in LTC4S may indicate an increased risk of chronic urticaria when treated with acetylsalicylic acid. Metabolism. [, FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. Trends Endocrinol Metab. The active site of COX-2 is, however, slightly larger than the active site of COX-1, so that arachidonic acid (which later becomes prostaglandins) manages to bypass the aspirin molecule inactivating COX-2 11,12. The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Dasatinib. [, Barrow EW, Bourne PC, Barrow WW: Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim. Generic Name Omeprazole DrugBank Accession Number DB00338 Background. An oral dose of hydrochlorothiazide is 65-75% bioavailable, with a T max of 1-5 hours, and a C max of 70-490ng/mL following doses of 12.5-100mg. Systemic or oral antifungals may decrease activity of probiotic. All data are derived Hydrocortisone may increase the anticoagulant activities of Acenocoumarol. pii: AAC.02392-16. Found in tandem arrangement with CYP2D6*4. ASA is also indicated for various other purposes, due to its ability to inhibit platelet aggregation. Tazobactam broadens the spectrum of piperacillin 11 and ceftolozane 14 by making them effective against organisms that express beta-lactamase and would normally degrade them. [, Shigeev S: Severity of opiate intoxication to gender and age. 2014 Nov 26;14:91. doi: 10.1186/1472-6823-14-91. Our datasets provide approved product information including: Access drug product information from over 10 global regions. 1996 Jul 31;101(1A):40S-46S. 2008 Mar 15;111(6):3097-107. doi: 10.1182/blood-2007-08-104372.
Mechanism 2007 Aug 14;104(33):13283-8. Tranexamic acid has roughly eight times With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. duvelisib. Mechanism of action. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Cancer Metastasis Rev. The absence of an interaction does not necessarily mean no interactions exist. 1978 Nov;62(5 Pt 2 Suppl):867-72. Its absorption is increased with concomitant administration of a high-fat meal.19, The mean apparent volume of distribution of doxepin is reported to be of 20 L/kg.6, Equilibrium dialysis indicates a mean protein binding of 75.5% for doxepin and 76% for desmethyldoxepin.3, Doxepin is extensively metabolized to N-desmethyldoxepin which is a biologically active metabolite and other inactive metabolites.2 The first-pass metabolism accounts for 55-87% of the administered dose.5 After, the secondary metabolism is driven by the transformation of N-desmethyldoxepin to its glucuronide conjugates.19, The main metabolic enzymes involved in the transformation of doxepin are the members of the cytochrome P450 family, CYP2C19 and CYP2D6 with minor involvement of CYP1A2 and CYP2C9.19, Hover over products below to view reaction partners, The elimination profile of doxepin is presented as biphasic.3 It is excreted in the urine mainly in the form of glucuronide conjugates. Mechanism of action. [, Kamel IR, Wendling WW, Chen D, Wendling KS, Harakal C, Carlsson C: N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. doi: 10.1002/prp2.357. 2018 Sep 26;6:e5667. Acetylsalicylic acid is hydrolyzed in the plasma to salicylic acid. However, doxepin is known to be a selective histamine H1 receptor blocker.1 This effect on histamine receptors indicates effectiveness in skin conditions.7, Breaking its function according to the different effect, doxepin's antidepressive action is primarily associated with the inhibition of the central nervous system biogenic amine reuptake; more specifically, norepinephrine and serotonin at synaptic nerve terminals. [, Luciani MG, Campregher C, Gasche C: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.
Artemether Mechanism of action. Contribution of the cytochrome P450 3A (CYP3A) subfamily. salicylates, acetate ester, benzoic acids (, Heterozygous Familial Hypercholesterolemia (HeFH), Major Adverse Cardiovascular and Cerebrovascular Events (MACCE), Myocardial Infarction (MI), first occurrence, Tumor necrosis factor-inducible gene 6 protein, Inhibitor of nuclear factor kappa-B kinase subunit beta, Extracellular signal-regulated kinase (ERK), B01AC Platelet aggregation inhibitors excl. Pharmacogenetics. Epub 2014 Feb 24.
Menadione It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. [, Wang L, Wu J, Zhang W, Zhi Y, Wu Y, Jiang R, Yang R: Effects of aspirin on the ERK and PI3K/Akt signaling pathways in rats with acute pulmonary embolism. 2013 Dec;4(Suppl 1):S94-8. Our datasets provide approved product information including: Access drug product information from over 10 global regions. 2002;507:571-7. Chronic toxicity studies were performed in rodents. [, Zawertailo LA, Kaplan HL, Busto UE, Tyndale RF, Sellers EM: Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study. [, Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. J Pharmacol Exp Ther. 1981 Apr 9;70(4):501-9. 2005 Oct 15;65(20):9185-9. [, Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM: Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. The serum concentration of Abemaciclib can be increased when it is combined with Morphine. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. [, O'Neill EA: A new target for aspirin. Avatrombopag: Avatrombopag may decrease the excretion rate of Cladribine which could result in a higher serum level. Succinate 100 mg/vial, (11)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione, Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Avatrombopag: Avatrombopag may decrease the excretion rate of Cladribine which could result in a higher serum level. This reaction requires the hydroquinone (reduced) form of K3, menadiol, produced by an unidentified enzyme. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. (1990). Drug Metab Dispos. Acidic urine generally aids in reabsorption of salicylate by the renal tubules, while alkaline urine increases excretion Label. Future Oncol.
Tazobactam duvelisib. doi: 10.1016/s0002-9343(96)00137-4. Acetylsalicylic acid may increase the anticoagulant activities of Acenocoumarol. Epub 2014 Apr 1.
Omeprazole: Uses, Interactions, Mechanism of Mechanism 1998 Nov 5;396(6706):15, 17. doi: 10.1038/23810. Best Pract Res Clin Endocrinol Metab. 1998 Nov;287(2):538-44. J Toxicol Sci.
and Lactation Database (LactMed Br J Clin Pharmacol. [, Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ: Endothelin. Stevens-Johnson syndrome, rare cases of toxic epidermal necrolysis, and rash-related deaths; incidence 0.3-0.8% in 2-17 yo and 0.08%-0.3% in adults; age is only risk factor identified as predictive for risk of rash occurrence or severity; other risk factors may incl. phenytoin will decrease the level or effect of dronedarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use immediate-release formulations in scenarios requiring rapid onset of action Label,21. [, Talbodec A, Berkane N, Blandin V, Breittmayer JP, Ferrari E, Frelin C, Vigne P: Aspirin and sodium salicylate inhibit endothelin ETA receptors by an allosteric type of mechanism. In Rang and Dale's Pharmacology (9th ed.). 2007 Aug;2(8):1116-40. [, Jiang DQ, Liu H, Zhang SB, Zhang XL: Aspirin inhibits tumor necrosis factor-alpha-stimulated fractalkine expression in human umbilical vein endothelial cells. Lancet. The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Acetazolamide. Co-administration may enhance CNS adverse effects such as drowsiness and sedation. The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Acetohexamide. selumetinib. 2000 Oct;292(10):496-9. Anesth Analg. Generic Name Apixaban DrugBank Accession Number DB06605 Background. [, Vane JR, Bakhle YS, Botting RM: Cyclooxygenases 1 and 2. Breast Cancer Res Treat. Aspirin is classified as a non-selective cyclooxygenase (COX) inhibitor 11,14 and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others 19. Clin Cancer Res. Generic Name Nitrofurantoin DrugBank Accession Number DB00698 Background. 2004 Dec;48(12):4643-9. Avoid life-threatening adverse drug events & improve clinical decision support. Avoid grapefruit products. Expert Opin Drug Metab Toxicol. 1 It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. 7. doi: 10.1128/AAC.02045-17. This disorders can appear in different forms such as phobias, panic, obsessive-compulsive disorder and post-traumatic stress disorder.15, Insomnia is a sleep disorder that directly affects the quality of life of the individual. [, Kutuk O, Basaga H: Aspirin inhibits TNFalpha- and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis. 2006 Nov;91(11):4544-51. U.S. Patent US4563443, issued March, 1981. 1993 Dec;46(6):827-32. doi: 10.1016/0960-0760(93)90325-q. 2012 Jan;114(1):122-8. doi: 10.1213/ANE.0b013e318232e922. 2000 Apr;57(4):797-804. 1998 Oct;22(6):531-6. J Pharmacol Exp Ther. Avoid life-threatening adverse drug events & improve clinical decision support.
Mechanism The volume of distribution varies widely from one study to another with Epub 2007 Aug 7. Embil K. and Torosian G. 1982. For decreasing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks (TIA) Label. [, Raffa RB: A novel approach to the pharmacology of analgesics. Epub 2006 Feb 23. Label It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Dasatinib, at nanomolar concentrations, inhibits the following kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFR. Label It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. However, ibuprofen is considered an NSAID and thus it is a non-selective inhibitor of cyclooxygenase, which is an enzyme involved in prostaglandin (mediators of pain and fever) and thromboxane (stimulators of blood clotting) synthesis via the arachidonic acid pathway. Tranexamic acid is a synthetic analog of the amino acid lysine.It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen.This decreases the conversion of plasminogen to plasmin, preventing fibrin degradation and preserving the framework of fibrin's matrix structure.
Dilantin Plasma concentrations of aspirin following after administration of the extended-release form are mostly undetectable 4-8 hours after ingestion of a single dose. Clinical chemistry: techniques, principles and correlations (6th ed.). Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor. 2 It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other [, Qorri B, Harless W, Szewczuk MR: Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells. Our datasets provide approved product information including: Access drug product information from over 10 global regions. Volume of distribution. The metabolism of Dextromethorphan can be decreased when combined with Acalabrutinib. 2014 Jul 8;111(1):61-7. doi: 10.1038/bjc.2014.271. Absorption. 2 This drug is more resistant to the 1980 Nov;47(5):371-6. 2006 May;69(5):1510-2. Free Radic Biol Med. Mechanism of action. 2002 Dec;303(3):1029-37. Pain. Inhibition of this enzyme slows the breakdown of GLP-1 and glucose-dependant insulinotropic polypeptide Avatrombopag: The serum concentration of Avatrombopag can be increased when it is combined with Linagliptin. 10 Hydrocortisone has a wide therapeutic index 8 and a moderate duration of action. Suggested therapeutic alternatives to those drugs are provided, where appropriate. This condition can lead to emotional and physical disturbances that can decrease the ability of a person to function in a regular environment.14, Anxiety is a normal reaction of the body towards a normal danger. It is also used for symptomatic pain relief after surgical and dental procedures Label. Acetylsalicylic acid (ASA) blocks prostaglandin synthesis. Epub 2006 Apr 6. 2007 May;41(5):737-41. In older age, nephrotoxicity from salicylates increases, and the risk of upper gastrointestinal hemorrhage is increased, with higher rates of mortality 8. These effects are observed at high doses where its affinity for H1 histamine receptor is lost and its binding to other receptors is observed.1, The maximal antidepressive effects of doxepin are present around two weeks following initiation of therapy.6 However, the sedative effects of doxepin, usually used for the treatment of insomnia or anxiety, are observed immediately after administration.7, Doxepin exact mechanism of action is not very clear.